Overview

Bidirectional communication between neurons and astrocytes is critical for the development, maintenance and function of neural circuits. Disruptions in neuron-astrocyte communication are associated with neurodegenerative and neuropsychiatric disorders. Our goal is to develop a mechanistic and functional understanding of the interactions between neurons and astrocytes, and how the coordinated activity of neurons and astrocyte influence behavioral outputs. We investigate these questions using an interdisciplinary approach, with an emphasis on circuit manipulation, in-vivo imaging with high spatiotemporal resolution, and large-scale data analysis of neuron-astrocyte interactions.